The Science Behind Magnesium Glycinate: Why Bioavailability Matters
Are you getting enough magnesium? Probably not. Nearly half of American population is magnesium deficient (1), and many supplements fail to offer real benefits due to poor absorption. Since magnesium supports over 300 biochemical processes in your body (2), choosing the right form is crucial for optimal health.
Which Form of Magnesium Absorbs Better and Why?
Magnesium bioavailability depends on the type of carrier molecule they are bound to (3, 4).
Salt-based forms, such as magnesium oxide, have lower solubility, making them harder to absorb and reducing their overall effectiveness. Magnesium bound to an acid-based carrier, like magnesium citrate, do absorb more effectively but causes stomach upset and diarrhea.
Amino acids are among the most effective carrier types, as seen in magnesium glycinate that is well absorbed and efficiently utilized by the body.
How Amino Acid Carriers Enhance Magnesium Absorption
When magnesium is bound to amino acids, it is absorbed through amino acid transport pathways rather than traditional mineral ion channels (3). This enhances magnesium’s bioavailability in several ways including improved stability, efficient transport, and better cellular uptake.
Why Choose MyCern’s Formula?
In MyCern Magnesium Glycinate, magnesium is chelated between two glycine molecules, allowing it to pass easily through the intestinal lining for superior absorption and maximum benefits. Another advantage of glycine is its compact structure, which enables a higher proportion of magnesium in our formula. Unlike other forms, it is gentle on the stomach and does not cause a laxative effect.
Health Benefits of Magnesium Glycinate
Magnesium Glycinate helps you feel calmer by supporting GABA, your brain’s main relaxation neurotransmitter (5). GABA reduces stress by slowing down overactive nerve signals, helping you feel more relaxed and balanced. While glycine adds to the calming process, making it even more helpful in alleviating anxiety and improving mood (6, 7).
This powerful combination also supports better sleep, as GABA slows brain activity, helping you fall asleep faster and enjoy deeper, more restful sleep (8).
Another benefit of magnesium is that it strengthens bones and supports healthy joints (9). Studies show that magnesium also supports cartilage health, which may help ease joint discomfort caused by aging or daily activities (10).
And that’s just the beginning—MyCern Magnesium Glycinate brings you a fusion of health benefits in one easy-to-absorb formula.
References
1. Perspective: The Case for an Evidence-Based Reference Interval for Serum Magnesium: The Time Has Come. 2016. Advances in Nutrition.
2. Magnesium. 2022. National Institute of Health.
3. Bioavailability of magnesium food supplements: A systematic review. 2021. Nutrition.
4. Predicting and Testing Bioavailability of Magnesium Supplements. 2019. Nutrients.
5. Magnesium in neuroses and neuroticism. 2011. NIH Bookshelf.
6. A New Way to get Relaxed with Magnesium Supplement. 2023. Journal of Marketing & Supply Chain Management.
7. Molecular mechanisms defining application of glycine and zinc combination in correction of stress and anxiety main manifestations. 2022. Pharmacy & Pharmacology.
8. Newer Technologies for Use and Delivery of Nutraceuticals to Cure Insomnia and Induce Sleep: In Nutraceuticals in Insomnia and Sleep Problems. 2025. Apple Academic Press.
9. Magnesium in joint health and osteoarthritis. 2021. Nutrition Research.
10. Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins. 2010. Osteoarthritis and Cartilage.
About the Author
Dr. Tariq Ismail (PhD, Postdoc)
Dr. Ismail is an Associate Professor and expert in food science and medical nutrition with 16+ years of experience. He holds a PhD in Food Science and a Postdoc in Nutritional Sciences from Lund University, Sweden. His expertise includes medical nutrition therapy, supplements, nutraceuticals, gut health, functional foods, and product development.
He has authored 100+ peer-reviewed articles (impact factor >300), contributed to scientific books, and leads innovative research projects while mentoring graduate students. As head of a product development lab, he creates advanced food formulations and consults for organizations such as CABI, Mott MacDonald, GAIN, SMEDA, and PARC.
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Contribution to MyCern
Dr. Ismail contributes to MyCern by translating complex supplement science into clear, evidence-based insights that help consumers make informed health decisions. He focuses on researching and sharing how the right supplements can support health, performance, and long-term vitality.